Objective: To explore the value of integrin-linked kinase (ILK) in the diagnosis of gastric cancer, its mechanism of action in the pathogenesis and its influence on tumor metastasis. Methods: Collect 100 cases of gastric cancer diagnosed pathologically, detect the positive expression of ILK, and analyze its biological characteristics. Results: The positive rate of ILK in gastric cancer tissue (57.0%) is significantly higher than that in the control group (12%), and the positive rate of ILK gradually increased with the progress of superficial gastritis, chronic atrophic gastritis with atypical hyperplasia and gastric cancer. The differences between the four groups are statistically significant. There is a significant difference in the positive rate of ILK among well-differentiated, moderately-differentiated, poorly-differentiated and undifferentiated adenocarcinomas (P<0.001). The positive rate (25%) of ILK in the uninvaded serosal layer (T1+T2) is significantly lower than the positive rate (75.0%) in the invaded serosal layer (T3+T4). There is a significant difference in the positive rate of ILK in stage I, II, III and IV (P<0.001). In the localized type (I+II), the positive rate of ILK (24.39%) is significantly lower than that of the invasive type (III+IV) (79.66%). The positive rate of ILK in patients without lymph node metastasis (30.23%) is significantly lower than that of patients with lymph node metastasis (77.19%). Conclusion: The positive rate of ILK in gastric cancer tissue is significantly higher than that in adjacent tissues. The higher the positive rate, the worse the prognosis. ILK is an independent risk factor affecting the prognosis of patients.
| Published in | American Journal of Biomedical and Life Sciences (Volume 8, Issue 4) |
| DOI | 10.11648/j.ajbls.20200804.18 |
| Page(s) | 119-125 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Gastric Cancer, Degree of Differentiation, Borrmann Classification, TNM Staging, Lymph Node Metastasis, Integrin-Linked Kinase
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APA Style
Jianzhang Hou, Yong Li. (2020). Expression of Integrin-linked Kinase in Gastric Cancer and Its Relationship with Clinicopathological Characteristics. American Journal of Biomedical and Life Sciences, 8(4), 119-125. https://doi.org/10.11648/j.ajbls.20200804.18
ACS Style
Jianzhang Hou; Yong Li. Expression of Integrin-linked Kinase in Gastric Cancer and Its Relationship with Clinicopathological Characteristics. Am. J. Biomed. Life Sci. 2020, 8(4), 119-125. doi: 10.11648/j.ajbls.20200804.18
AMA Style
Jianzhang Hou, Yong Li. Expression of Integrin-linked Kinase in Gastric Cancer and Its Relationship with Clinicopathological Characteristics. Am J Biomed Life Sci. 2020;8(4):119-125. doi: 10.11648/j.ajbls.20200804.18
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Download@article{10.11648/j.ajbls.20200804.18,
author = {Jianzhang Hou and Yong Li},
title = {Expression of Integrin-linked Kinase in Gastric Cancer and Its Relationship with Clinicopathological Characteristics},
journal = {American Journal of Biomedical and Life Sciences},
volume = {8},
number = {4},
pages = {119-125},
doi = {10.11648/j.ajbls.20200804.18},
url = {https://doi.org/10.11648/j.ajbls.20200804.18},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20200804.18},
abstract = {Objective: To explore the value of integrin-linked kinase (ILK) in the diagnosis of gastric cancer, its mechanism of action in the pathogenesis and its influence on tumor metastasis. Methods: Collect 100 cases of gastric cancer diagnosed pathologically, detect the positive expression of ILK, and analyze its biological characteristics. Results: The positive rate of ILK in gastric cancer tissue (57.0%) is significantly higher than that in the control group (12%), and the positive rate of ILK gradually increased with the progress of superficial gastritis, chronic atrophic gastritis with atypical hyperplasia and gastric cancer. The differences between the four groups are statistically significant. There is a significant difference in the positive rate of ILK among well-differentiated, moderately-differentiated, poorly-differentiated and undifferentiated adenocarcinomas (P<0.001). The positive rate (25%) of ILK in the uninvaded serosal layer (T1+T2) is significantly lower than the positive rate (75.0%) in the invaded serosal layer (T3+T4). There is a significant difference in the positive rate of ILK in stage I, II, III and IV (P<0.001). In the localized type (I+II), the positive rate of ILK (24.39%) is significantly lower than that of the invasive type (III+IV) (79.66%). The positive rate of ILK in patients without lymph node metastasis (30.23%) is significantly lower than that of patients with lymph node metastasis (77.19%). Conclusion: The positive rate of ILK in gastric cancer tissue is significantly higher than that in adjacent tissues. The higher the positive rate, the worse the prognosis. ILK is an independent risk factor affecting the prognosis of patients.},
year = {2020}
}
TY - JOUR T1 - Expression of Integrin-linked Kinase in Gastric Cancer and Its Relationship with Clinicopathological Characteristics AU - Jianzhang Hou AU - Yong Li Y1 - 2020/08/25 PY - 2020 N1 - https://doi.org/10.11648/j.ajbls.20200804.18 DO - 10.11648/j.ajbls.20200804.18 T2 - American Journal of Biomedical and Life Sciences JF - American Journal of Biomedical and Life Sciences JO - American Journal of Biomedical and Life Sciences SP - 119 EP - 125 PB - Science Publishing Group SN - 2330-880X UR - https://doi.org/10.11648/j.ajbls.20200804.18 AB - Objective: To explore the value of integrin-linked kinase (ILK) in the diagnosis of gastric cancer, its mechanism of action in the pathogenesis and its influence on tumor metastasis. Methods: Collect 100 cases of gastric cancer diagnosed pathologically, detect the positive expression of ILK, and analyze its biological characteristics. Results: The positive rate of ILK in gastric cancer tissue (57.0%) is significantly higher than that in the control group (12%), and the positive rate of ILK gradually increased with the progress of superficial gastritis, chronic atrophic gastritis with atypical hyperplasia and gastric cancer. The differences between the four groups are statistically significant. There is a significant difference in the positive rate of ILK among well-differentiated, moderately-differentiated, poorly-differentiated and undifferentiated adenocarcinomas (P<0.001). The positive rate (25%) of ILK in the uninvaded serosal layer (T1+T2) is significantly lower than the positive rate (75.0%) in the invaded serosal layer (T3+T4). There is a significant difference in the positive rate of ILK in stage I, II, III and IV (P<0.001). In the localized type (I+II), the positive rate of ILK (24.39%) is significantly lower than that of the invasive type (III+IV) (79.66%). The positive rate of ILK in patients without lymph node metastasis (30.23%) is significantly lower than that of patients with lymph node metastasis (77.19%). Conclusion: The positive rate of ILK in gastric cancer tissue is significantly higher than that in adjacent tissues. The higher the positive rate, the worse the prognosis. ILK is an independent risk factor affecting the prognosis of patients. VL - 8 IS - 4 ER -
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