Heamocoagulase Agkistrodon on Hemostatic Effectivity on Posterior Lumbar Operation

Feng Hao; Chen Huanshi; Bai Ruifei; Li Wei

doi:doi:10.11648/j.cmr.20200906.13

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Heamocoagulase Agkistrodon on Hemostatic Effectivity on Posterior Lumbar Operation

Feng Hao, Chen Huanshi, Bai Ruifei, Li Wei

Published in Clinical Medicine Research (Volume 9, Issue 6)

Received: 16 December 2020 Accepted: 22 December 2020 Published: 28 December 2020

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Abstract

Objective: Perioperative bleeding volume of posterior spinal surgery is relatively large. This study was aimed to evaluate the hemostatic effect of Hemocoagulase agkistrodon for injection on open lumbar spine surgery. Methods: In this study, a prospective, blinded, randomized, and controlled clinical trial was used to observe the hemostatic effect of 2U intravenous injection of Hemocoagulase agkistrodon 15 minutes before surgery on the posterior lumbar open surgery. A total of 60 cases were included in this experimental study, 30 cases in the study group (2U agkistrodon hemagglutinin for intravenous injection 15 minutes before surgery) and 30 cases in the control group (Inject normal saline 15 minutes before surgery). We use SAS software to simulate and generate random codes. The third-party blinding method is adopted, that is, a specialized nurse is assigned to allocate study drugs in the order of random codes and intravenously according to the plan. We statistically analyzed the bleeding volume and postoperative drainage volume of posterior lumbar spine surgery, and the changes of coagulation indexes in the two groups. Results: All the selected patients successfully completed the operation, their wounds healed and were discharged from the hospital, and no complications such as infection and thrombosis occurred during the hospitalization. The two groups of patients’ coagulation function indicators include prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), fibrinogen quantification (FIB), and D2 polymer. The difference was not statistically significant. However, comparing the intraoperative blood loss, 24h postoperative drainage, and postoperative total drainage between the two groups, the experimental group was better than the control group. Conclusion: Intravenous injection of Agkistrodon hemagglutinin 2U 15 minutes before surgery can have a satisfactory hemostatic effect on the posterior lumbar spine surgical incision. It can not only significantly reduce the amount of bleeding from surgical incisions, but also has no significant effect on the body's coagulation function. It is a safe and effective hemostatic drug.

Published in	Clinical Medicine Research (Volume 9, Issue 6)
DOI	10.11648/j.cmr.20200906.13
Page(s)	136-139
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Heamocoagulase Agkistrodon, Hemostasis, Open Spinal Surgery, Lumbar Degeneration

References

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APA Style

Feng Hao, Chen Huanshi, Bai Ruifei, Li Wei. (2020). Heamocoagulase Agkistrodon on Hemostatic Effectivity on Posterior Lumbar Operation. Clinical Medicine Research, 9(6), 136-139. https://doi.org/10.11648/j.cmr.20200906.13

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ACS Style

Feng Hao; Chen Huanshi; Bai Ruifei; Li Wei. Heamocoagulase Agkistrodon on Hemostatic Effectivity on Posterior Lumbar Operation. Clin. Med. Res. 2020, 9(6), 136-139. doi: 10.11648/j.cmr.20200906.13

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AMA Style

Feng Hao, Chen Huanshi, Bai Ruifei, Li Wei. Heamocoagulase Agkistrodon on Hemostatic Effectivity on Posterior Lumbar Operation. Clin Med Res. 2020;9(6):136-139. doi: 10.11648/j.cmr.20200906.13

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@article{10.11648/j.cmr.20200906.13,
  author = {Feng Hao and Chen Huanshi and Bai Ruifei and Li Wei},
  title = {Heamocoagulase Agkistrodon on Hemostatic Effectivity on Posterior Lumbar Operation},
  journal = {Clinical Medicine Research},
  volume = {9},
  number = {6},
  pages = {136-139},
  doi = {10.11648/j.cmr.20200906.13},
  url = {https://doi.org/10.11648/j.cmr.20200906.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20200906.13},
  abstract = {Objective: Perioperative bleeding volume of posterior spinal surgery is relatively large. This study was aimed to evaluate the hemostatic effect of Hemocoagulase agkistrodon for injection on open lumbar spine surgery. Methods: In this study, a prospective, blinded, randomized, and controlled clinical trial was used to observe the hemostatic effect of 2U intravenous injection of Hemocoagulase agkistrodon 15 minutes before surgery on the posterior lumbar open surgery. A total of 60 cases were included in this experimental study, 30 cases in the study group (2U agkistrodon hemagglutinin for intravenous injection 15 minutes before surgery) and 30 cases in the control group (Inject normal saline 15 minutes before surgery). We use SAS software to simulate and generate random codes. The third-party blinding method is adopted, that is, a specialized nurse is assigned to allocate study drugs in the order of random codes and intravenously according to the plan. We statistically analyzed the bleeding volume and postoperative drainage volume of posterior lumbar spine surgery, and the changes of coagulation indexes in the two groups. Results: All the selected patients successfully completed the operation, their wounds healed and were discharged from the hospital, and no complications such as infection and thrombosis occurred during the hospitalization. The two groups of patients’ coagulation function indicators include prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), fibrinogen quantification (FIB), and D2 polymer. The difference was not statistically significant. However, comparing the intraoperative blood loss, 24h postoperative drainage, and postoperative total drainage between the two groups, the experimental group was better than the control group. Conclusion: Intravenous injection of Agkistrodon hemagglutinin 2U 15 minutes before surgery can have a satisfactory hemostatic effect on the posterior lumbar spine surgical incision. It can not only significantly reduce the amount of bleeding from surgical incisions, but also has no significant effect on the body's coagulation function. It is a safe and effective hemostatic drug.},
 year = {2020}
}

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TY - JOUR
T1 - Heamocoagulase Agkistrodon on Hemostatic Effectivity on Posterior Lumbar Operation
AU - Feng Hao
AU - Chen Huanshi
AU - Bai Ruifei
AU - Li Wei
Y1 - 2020/12/28
PY - 2020
N1 - https://doi.org/10.11648/j.cmr.20200906.13
DO - 10.11648/j.cmr.20200906.13
T2 - Clinical Medicine Research
JF - Clinical Medicine Research
JO - Clinical Medicine Research
SP - 136
EP - 139
PB - Science Publishing Group
SN - 2326-9057
UR - https://doi.org/10.11648/j.cmr.20200906.13
AB - Objective: Perioperative bleeding volume of posterior spinal surgery is relatively large. This study was aimed to evaluate the hemostatic effect of Hemocoagulase agkistrodon for injection on open lumbar spine surgery. Methods: In this study, a prospective, blinded, randomized, and controlled clinical trial was used to observe the hemostatic effect of 2U intravenous injection of Hemocoagulase agkistrodon 15 minutes before surgery on the posterior lumbar open surgery. A total of 60 cases were included in this experimental study, 30 cases in the study group (2U agkistrodon hemagglutinin for intravenous injection 15 minutes before surgery) and 30 cases in the control group (Inject normal saline 15 minutes before surgery). We use SAS software to simulate and generate random codes. The third-party blinding method is adopted, that is, a specialized nurse is assigned to allocate study drugs in the order of random codes and intravenously according to the plan. We statistically analyzed the bleeding volume and postoperative drainage volume of posterior lumbar spine surgery, and the changes of coagulation indexes in the two groups. Results: All the selected patients successfully completed the operation, their wounds healed and were discharged from the hospital, and no complications such as infection and thrombosis occurred during the hospitalization. The two groups of patients’ coagulation function indicators include prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), fibrinogen quantification (FIB), and D2 polymer. The difference was not statistically significant. However, comparing the intraoperative blood loss, 24h postoperative drainage, and postoperative total drainage between the two groups, the experimental group was better than the control group. Conclusion: Intravenous injection of Agkistrodon hemagglutinin 2U 15 minutes before surgery can have a satisfactory hemostatic effect on the posterior lumbar spine surgical incision. It can not only significantly reduce the amount of bleeding from surgical incisions, but also has no significant effect on the body's coagulation function. It is a safe and effective hemostatic drug.
VL - 9
IS - 6
ER -

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Author Information

Feng Hao

Department of Orthopedics, Liuzhou Municipal Liutie Central Hospital, Liuzhou, China
Chen Huanshi

Department of Orthopedics, Liuzhou Municipal Liutie Central Hospital, Liuzhou, China
Bai Ruifei

Department of Orthopedics, Liuzhou Municipal Liutie Central Hospital, Liuzhou, China
Li Wei

Department of Orthopedics, Liuzhou Municipal Liutie Central Hospital, Liuzhou, China

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APA Style

Feng Hao, Chen Huanshi, Bai Ruifei, Li Wei. (2020). Heamocoagulase Agkistrodon on Hemostatic Effectivity on Posterior Lumbar Operation. Clinical Medicine Research, 9(6), 136-139. https://doi.org/10.11648/j.cmr.20200906.13

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ACS Style

Feng Hao; Chen Huanshi; Bai Ruifei; Li Wei. Heamocoagulase Agkistrodon on Hemostatic Effectivity on Posterior Lumbar Operation. Clin. Med. Res. 2020, 9(6), 136-139. doi: 10.11648/j.cmr.20200906.13

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AMA Style

Feng Hao, Chen Huanshi, Bai Ruifei, Li Wei. Heamocoagulase Agkistrodon on Hemostatic Effectivity on Posterior Lumbar Operation. Clin Med Res. 2020;9(6):136-139. doi: 10.11648/j.cmr.20200906.13

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@article{10.11648/j.cmr.20200906.13,
  author = {Feng Hao and Chen Huanshi and Bai Ruifei and Li Wei},
  title = {Heamocoagulase Agkistrodon on Hemostatic Effectivity on Posterior Lumbar Operation},
  journal = {Clinical Medicine Research},
  volume = {9},
  number = {6},
  pages = {136-139},
  doi = {10.11648/j.cmr.20200906.13},
  url = {https://doi.org/10.11648/j.cmr.20200906.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20200906.13},
  abstract = {Objective: Perioperative bleeding volume of posterior spinal surgery is relatively large. This study was aimed to evaluate the hemostatic effect of Hemocoagulase agkistrodon for injection on open lumbar spine surgery. Methods: In this study, a prospective, blinded, randomized, and controlled clinical trial was used to observe the hemostatic effect of 2U intravenous injection of Hemocoagulase agkistrodon 15 minutes before surgery on the posterior lumbar open surgery. A total of 60 cases were included in this experimental study, 30 cases in the study group (2U agkistrodon hemagglutinin for intravenous injection 15 minutes before surgery) and 30 cases in the control group (Inject normal saline 15 minutes before surgery). We use SAS software to simulate and generate random codes. The third-party blinding method is adopted, that is, a specialized nurse is assigned to allocate study drugs in the order of random codes and intravenously according to the plan. We statistically analyzed the bleeding volume and postoperative drainage volume of posterior lumbar spine surgery, and the changes of coagulation indexes in the two groups. Results: All the selected patients successfully completed the operation, their wounds healed and were discharged from the hospital, and no complications such as infection and thrombosis occurred during the hospitalization. The two groups of patients’ coagulation function indicators include prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), fibrinogen quantification (FIB), and D2 polymer. The difference was not statistically significant. However, comparing the intraoperative blood loss, 24h postoperative drainage, and postoperative total drainage between the two groups, the experimental group was better than the control group. Conclusion: Intravenous injection of Agkistrodon hemagglutinin 2U 15 minutes before surgery can have a satisfactory hemostatic effect on the posterior lumbar spine surgical incision. It can not only significantly reduce the amount of bleeding from surgical incisions, but also has no significant effect on the body's coagulation function. It is a safe and effective hemostatic drug.},
 year = {2020}
}

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