On June 04, 2020, Chile had 113,628 cases COVID-19, 1275 deaths, 1450 patients were on invasive mechanical ventilation (IMV). The objective was describing the characteristics on admission and their relationship with the condition at discharge of patients with positive real-time polymerase chain reaction test for SARS CoV-2 (RT-PCR) in a tertiary health center. Methods: Retrospective and observational cohort study of 529 consecutive patients with positive RT-PCR for SARS CoV-2, discharged between March 14 and June 4, 2020 from Clinica Davila, Santiago. Demographic data, laboratory tests, Quality Adjusted Life Years (QALY), medical insurance, ventilatory assistance, and discharge condition were collected. Differences were evaluated by chi-square test, student’s t test, or Mann–Whitney U test. Logistic regression analysis was performed to identify variables that were predictive of condition at discharge. Results: A total of 529 patients were included (median age, 49 years [interquartile range {IQR}, 37-62; range, 0-97 years]; 45% women). The most common comorbidities were hypertension (171, 32.3%) and diabetes mellitus (98, 18.5%), On admission 352 patients (66.5%) had respiratory symptoms and 177 (33.4%) had other symptoms or other diagnoses. The median (IQR) PaO2 / FiO2 on admission of survivors, non-survivors and transferred were 316 (261-360), 167 (80-268) and 212 (130-261) respectively. At discharge, 448 (84.7%) were survivors, 54 (10.2%) non-survivors, and 27 (5.1%) were transferred to other centers. Median age of survivors and non-survivors was 46 (36-59) and 75.5 (66-84) years. Of the 116 patients (21,9%) who received support ventilation, 67 were discharged alive (57.8%), 28 died (24%), and 21 (18%) were transferred to another hospital. The variables associated with risk of death were: age ≥ 60 years (OR 15.3; 95% CI: 7.25–32.2; P = 0.001); QALY score ≤ 15 points (OR 14.01; 95% CI: 4.82 -40.67; P = 0.001); state health insurance (OR, 2.82; 95% CI: 1.38–5.77; P = 0.004); PaO2 / FiO2 on admission ≤ 200 (OR 5.2; 95% CI: 1.94-13.94; P = 0.001) and high sensitivity T Troponin ≥ 15 ng / L (OR 5.16; 95% CI: 1.95-13.64; P = 0.001). Conclusions: this cohort showed that on admission COVID-19 patients, the PaO2 / FiO2, creatinine and high sensitivity T troponin at the described cut-off points had prognostic value. At discharge, the non-survivors were the older, most often had state health insurance and their QALY scores were significantly lower.
| Published in | Clinical Medicine Research (Volume 10, Issue 1) |
| DOI | 10.11648/j.cmr.20211001.11 |
| Page(s) | 1-8 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
Coronavirus Infections, Quality Adjusted Life Years, Health Insurance, Pcr Sars CoV2, Prognostic Factors, COVID-19
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APA Style
Cesar Maquilon Ortiz, Jonas Alberto Gongora, Monica Antolini Toledo, Nicolas Fernando Valdes, Angela Benavente, et al. (2021). Clinical and Demographic Characteristics on Admission and Their Prognostic Value at Discharge in 529 Consecutive COVID-19 Patients in Santiago, Chile. Clinical Medicine Research, 10(1), 1-8. https://doi.org/10.11648/j.cmr.20211001.11
ACS Style
Cesar Maquilon Ortiz; Jonas Alberto Gongora; Monica Antolini Toledo; Nicolas Fernando Valdes; Angela Benavente, et al. Clinical and Demographic Characteristics on Admission and Their Prognostic Value at Discharge in 529 Consecutive COVID-19 Patients in Santiago, Chile. Clin. Med. Res. 2021, 10(1), 1-8. doi: 10.11648/j.cmr.20211001.11
AMA Style
Cesar Maquilon Ortiz, Jonas Alberto Gongora, Monica Antolini Toledo, Nicolas Fernando Valdes, Angela Benavente, et al. Clinical and Demographic Characteristics on Admission and Their Prognostic Value at Discharge in 529 Consecutive COVID-19 Patients in Santiago, Chile. Clin Med Res. 2021;10(1):1-8. doi: 10.11648/j.cmr.20211001.11
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author = {Cesar Maquilon Ortiz and Jonas Alberto Gongora and Monica Antolini Toledo and Nicolas Fernando Valdes and Angela Benavente and Maria Gabriela Bofill and Macarena Urra and Diego Rojas Carvajal and Javiera Huidobro Navarro and Bernardita Alvarado Breton and Maria Carolina Asenjo and Cherie Gutierrez Rojas and Jose Gajardo and Patricia Cisternas and Guillermo Garcia and Juan Pablo Peralta and Lenny Loor Garcia and Annelise Sepulveda and Cecilia Tapia and Luis Fernando Mallea and Felipe Rivera and Ezio Parodi and Jyh Kae Nien},
title = {Clinical and Demographic Characteristics on Admission and Their Prognostic Value at Discharge in 529 Consecutive COVID-19 Patients in Santiago, Chile},
journal = {Clinical Medicine Research},
volume = {10},
number = {1},
pages = {1-8},
doi = {10.11648/j.cmr.20211001.11},
url = {https://doi.org/10.11648/j.cmr.20211001.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20211001.11},
abstract = {On June 04, 2020, Chile had 113,628 cases COVID-19, 1275 deaths, 1450 patients were on invasive mechanical ventilation (IMV). The objective was describing the characteristics on admission and their relationship with the condition at discharge of patients with positive real-time polymerase chain reaction test for SARS CoV-2 (RT-PCR) in a tertiary health center. Methods: Retrospective and observational cohort study of 529 consecutive patients with positive RT-PCR for SARS CoV-2, discharged between March 14 and June 4, 2020 from Clinica Davila, Santiago. Demographic data, laboratory tests, Quality Adjusted Life Years (QALY), medical insurance, ventilatory assistance, and discharge condition were collected. Differences were evaluated by chi-square test, student’s t test, or Mann–Whitney U test. Logistic regression analysis was performed to identify variables that were predictive of condition at discharge. Results: A total of 529 patients were included (median age, 49 years [interquartile range {IQR}, 37-62; range, 0-97 years]; 45% women). The most common comorbidities were hypertension (171, 32.3%) and diabetes mellitus (98, 18.5%), On admission 352 patients (66.5%) had respiratory symptoms and 177 (33.4%) had other symptoms or other diagnoses. The median (IQR) PaO2 / FiO2 on admission of survivors, non-survivors and transferred were 316 (261-360), 167 (80-268) and 212 (130-261) respectively. At discharge, 448 (84.7%) were survivors, 54 (10.2%) non-survivors, and 27 (5.1%) were transferred to other centers. Median age of survivors and non-survivors was 46 (36-59) and 75.5 (66-84) years. Of the 116 patients (21,9%) who received support ventilation, 67 were discharged alive (57.8%), 28 died (24%), and 21 (18%) were transferred to another hospital. The variables associated with risk of death were: age ≥ 60 years (OR 15.3; 95% CI: 7.25–32.2; P = 0.001); QALY score ≤ 15 points (OR 14.01; 95% CI: 4.82 -40.67; P = 0.001); state health insurance (OR, 2.82; 95% CI: 1.38–5.77; P = 0.004); PaO2 / FiO2 on admission ≤ 200 (OR 5.2; 95% CI: 1.94-13.94; P = 0.001) and high sensitivity T Troponin ≥ 15 ng / L (OR 5.16; 95% CI: 1.95-13.64; P = 0.001). Conclusions: this cohort showed that on admission COVID-19 patients, the PaO2 / FiO2, creatinine and high sensitivity T troponin at the described cut-off points had prognostic value. At discharge, the non-survivors were the older, most often had state health insurance and their QALY scores were significantly lower.},
year = {2021}
}
TY - JOUR
T1 - Clinical and Demographic Characteristics on Admission and Their Prognostic Value at Discharge in 529 Consecutive COVID-19 Patients in Santiago, Chile
AU - Cesar Maquilon Ortiz
AU - Jonas Alberto Gongora
AU - Monica Antolini Toledo
AU - Nicolas Fernando Valdes
AU - Angela Benavente
AU - Maria Gabriela Bofill
AU - Macarena Urra
AU - Diego Rojas Carvajal
AU - Javiera Huidobro Navarro
AU - Bernardita Alvarado Breton
AU - Maria Carolina Asenjo
AU - Cherie Gutierrez Rojas
AU - Jose Gajardo
AU - Patricia Cisternas
AU - Guillermo Garcia
AU - Juan Pablo Peralta
AU - Lenny Loor Garcia
AU - Annelise Sepulveda
AU - Cecilia Tapia
AU - Luis Fernando Mallea
AU - Felipe Rivera
AU - Ezio Parodi
AU - Jyh Kae Nien
Y1 - 2021/01/04
PY - 2021
N1 - https://doi.org/10.11648/j.cmr.20211001.11
DO - 10.11648/j.cmr.20211001.11
T2 - Clinical Medicine Research
JF - Clinical Medicine Research
JO - Clinical Medicine Research
SP - 1
EP - 8
PB - Science Publishing Group
SN - 2326-9057
UR - https://doi.org/10.11648/j.cmr.20211001.11
AB - On June 04, 2020, Chile had 113,628 cases COVID-19, 1275 deaths, 1450 patients were on invasive mechanical ventilation (IMV). The objective was describing the characteristics on admission and their relationship with the condition at discharge of patients with positive real-time polymerase chain reaction test for SARS CoV-2 (RT-PCR) in a tertiary health center. Methods: Retrospective and observational cohort study of 529 consecutive patients with positive RT-PCR for SARS CoV-2, discharged between March 14 and June 4, 2020 from Clinica Davila, Santiago. Demographic data, laboratory tests, Quality Adjusted Life Years (QALY), medical insurance, ventilatory assistance, and discharge condition were collected. Differences were evaluated by chi-square test, student’s t test, or Mann–Whitney U test. Logistic regression analysis was performed to identify variables that were predictive of condition at discharge. Results: A total of 529 patients were included (median age, 49 years [interquartile range {IQR}, 37-62; range, 0-97 years]; 45% women). The most common comorbidities were hypertension (171, 32.3%) and diabetes mellitus (98, 18.5%), On admission 352 patients (66.5%) had respiratory symptoms and 177 (33.4%) had other symptoms or other diagnoses. The median (IQR) PaO2 / FiO2 on admission of survivors, non-survivors and transferred were 316 (261-360), 167 (80-268) and 212 (130-261) respectively. At discharge, 448 (84.7%) were survivors, 54 (10.2%) non-survivors, and 27 (5.1%) were transferred to other centers. Median age of survivors and non-survivors was 46 (36-59) and 75.5 (66-84) years. Of the 116 patients (21,9%) who received support ventilation, 67 were discharged alive (57.8%), 28 died (24%), and 21 (18%) were transferred to another hospital. The variables associated with risk of death were: age ≥ 60 years (OR 15.3; 95% CI: 7.25–32.2; P = 0.001); QALY score ≤ 15 points (OR 14.01; 95% CI: 4.82 -40.67; P = 0.001); state health insurance (OR, 2.82; 95% CI: 1.38–5.77; P = 0.004); PaO2 / FiO2 on admission ≤ 200 (OR 5.2; 95% CI: 1.94-13.94; P = 0.001) and high sensitivity T Troponin ≥ 15 ng / L (OR 5.16; 95% CI: 1.95-13.64; P = 0.001). Conclusions: this cohort showed that on admission COVID-19 patients, the PaO2 / FiO2, creatinine and high sensitivity T troponin at the described cut-off points had prognostic value. At discharge, the non-survivors were the older, most often had state health insurance and their QALY scores were significantly lower.
VL - 10
IS - 1
ER -
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